How alcohol damages stem cell DNA and increases cancer risk

Open this

The study, which was published in the journal Nature, also kept an eye on the mechanism at how the body safeguards itself, resistant to alcohol.

Researchers from the Medical Research Council's lab of molecular biology at Cambridge University found that alcohol severely damages the DNA of stem cells in the blood and can subsequently lead to the formation of tumours.

But in this study, researchers gave diluted alcohol to mice.

Alcohol causes an increased risk of getting mouth, throat, oesophageal, larynx, breast, liver and bowel cancer, even in light drinkers.

When alcohol is broken down in the body it forms a poisonous chemical, known as acetaldehyde. Acetaldehyde could fabricate a long lasting change and is thought to efficiently cause mutations at the helm for cancer. "This paper provides very strong evidence that an alcohol metabolite causes DNA damage [including] to the all-important stem cells that go on to make tissues". Even minimal drinking might cause some level of DNA damage.

The results showed that mice lacking the critical ALDH enzyme - ALDH2 - sustained 4-times as much DNA damage in their cells after being given alcohol compared to those with the fully functioning ALDH2 enzyme.

This substance was found to be able to break down and distort DNA molecules within the blood stem cells.

The second line of defence involves a variety of DNA repair systems that allows cells to fix numerous different types of damage. "While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage", Professor Ketan Patel, the lead author of the study and scientist at the MRC Laboratory of Molecular Biology, said in a press-release.

Spirit Airlines passenger awoke to find stranger's hands down her trousers
When the flight landed at Detroit Metro Airport, Ramamoorthy was taken into custody by Wayne County Airport Authority. He also alleged that the woman had fallen asleep on his knee, and he was unaware of where he had placed his hands.

Working with mice in a laboratory, British scientists used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol.

Alcohol contains a toxin called acetaldehyde which, previous studies show, harms the DNA within cells. These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of energy.

'But it's important to remember alcohol clearance and DNA fix systems are not flawless and alcohol can still cause cancer in different ways - even in people whose defence mechanisms are intact'.

"24,000 cases of cancer a year could be prevented in the United Kingdom if nobody drank alcohol".

Millions of people - particularly from Southeast Asia - either lack these enzymes or carry faulty versions, said the team.

Scientists scrutinized at the influence aldehyde had on mice with and without these complicated ALDH enzymes and discovered that those who didn't have them agonized from four times as much damage to their DNA.

Scientists from Cancer Research UK warned in 2016 that alcohol would cause around 135,000 cancer deaths over the next two decades, and that by 2035, the UK could see 7,097 cancer deaths linked to drinking every year.

Related News:

  • Tottenham vs. West Ham live stream info, TV channel, time

    Tottenham vs. West Ham live stream info, TV channel, time

    Tottenham Hotspur were dumped out of the Carabao Cup back in October, 2017 losing 3-2 to West Ham. "It was disbelief. We have started to look stronger, but then we have lost a few goals.
    New leak shows off the Sony Xperia XA2, XA2 Ultra, and L2

    New leak shows off the Sony Xperia XA2, XA2 Ultra, and L2

    The Xperia XA2 will also feature a 5.2-inch display, while the bigger and the more premium sibling may have a 6.0-inch screen. Out of the three, two are said to be in the X-series - Xperia XA2 and XA2 Ultra , while the third one will be the Xperia L2 .
    SpaceX Falcon Heavy towers over historic Apollo launchpad

    SpaceX Falcon Heavy towers over historic Apollo launchpad

    Musk, though, has lowered expectations for the first Falcon Heavy launch, something he also did in his Instagram post. Guaranteed to be exciting, one way or another, ' Musk originally posted.
  • Joe Thornton has chunk ripped out magnificent beard in brawl

    Joe Thornton has chunk ripped out magnificent beard in brawl

    It appears both of them were feeling quite irritable heading into the game, for whatever reason. Fights in the National Hockey League are of course, common.
    Samsung's Exynos 9810 CPU is OFFICIAL (And She's A Monster)

    Samsung's Exynos 9810 CPU is OFFICIAL (And She's A Monster)

    The company claims Exynos 9810 is "the industry's most advanced 10nm process technology". On the GPU side, Samsung has opted for Arm's latest Mali-G72 technology.
    Nokia 6 (2018) goes official: Specs, price, release date and more

    Nokia 6 (2018) goes official: Specs, price, release date and more

    Elsewhere, the speaker setup on-board the original Nokia 6 came with dual amplifiers and support for Dolby Atmos sound technology. Nokia 8 (2018) doesn't feature an edge-to-edge display , which is quite common on mid-budget and flagship smartphones these days.
  • Mercedes-Benz G-Class photos leaked

    Mercedes-Benz G-Class photos leaked

    You have to crack open the driver's door to see where the big changes to the G-Class have been made. There's a new solid rear axle, too, with four control arms on each side and a Panhard rod.
    Kalanick to sell 29% of his stake in Uber amid SoftBank deal

    Kalanick to sell 29% of his stake in Uber amid SoftBank deal

    In a story December 28 about SoftBank's investment in Uber, The Associated Press misidentified Rajeev Misra as SoftBank's CEO. However, the investor consortium is also making a US$1.25 billion investment of fresh funding at the older, higher valuation.
    Jeopardy! host Alex Trebek recovering from head surgery

    Jeopardy! host Alex Trebek recovering from head surgery

    The host appeared in a brief video in which he acknowledged the incident and gave an update on his recovery. Trebek, 77, has been the host of Jeopardy! since its return to American television in 1984.
  • Apple acquires mobile development platform Buddybuild

    Besides BuddyBuild, Apple acquired TestFlight in 2014, which asked users to employ Xcode to take advantage of its service. Thus, it just makes sense that Apple wants to ensure that its platform and apps remain developer-friendly.
    Ryan Shazier's Dad Says His Son Has Regained Feeling In His Legs

    Ryan Shazier's Dad Says His Son Has Regained Feeling In His Legs

    He underwent spinal stabilization surgery three days after suffering the injury, and started rehabilitation a week after that. His father revealed that his son has feelings in his legs. "He's a long ways from the night when he was laying on the field".
    Iran stages pro-government rallies after days of unrest

    Iran stages pro-government rallies after days of unrest

    The official said the United States would also seek condemnation of Iran at The United Nations Human Rights Council in Geneva. Vice President Mike Pence said Wednesday the USA wants an agreement lasting longer.


Most liked

Baltimore Schools Close After Unheated Classrooms Hit 40 Degrees
One teacher told WJZ that some teachers have brought space heaters to school. "Thank you to everyone that has donated so far". A gofund.me effort to raise money for space heaters and winter coats was at just over $8,000 at around 9 a.m.

Caitlyn Jenner Slams The Kardashians Again: 'Of Course I Didn't Trust Them'
Except that she didn't tell all, deciding to hold back the final pages in which she talks about gender confirmation surgery. Last year, while chatting to Sirius XM's Andy Cohen , Cait said that she and step-daughter Khloe hadn't spoken for years.

United States freezes over $1 bn military aid to Pak over terror inaction
The US has been irked with the country since October when Pakistan had freed a Canadian-American family captured by militants. Allegations and denunciations were made by Bush regime as well as Obama regime and Pakistan was constantly asked to do more.

Cold Casualties: Sharksicles And Frozen Iguanas
Temperatures are expected to get into the 30s, but they won't stay there long enough to do much harm to the invasive populations. It seems that once frozen, there's no amount of warming that can bring them back.

Philippe Coutinho: Liverpool Forward Ruled Out Of FA Cup Derby With Everton
Warnock claimed he snubbed the Dutchman three years ago after he was offered the powerful centre-half while he was still playing for the Glasgow giants.

Rare 'blue supermoon' total eclipse to occur in Singapore on 31 January
This happens at least twice a year - but in this case, it's the fact that all these events coincide that makes it so cool. This place situated on its orbit is called the perigee, and the moon will appear a lot bigger and brighter than usual.

President Donald Trump to attend Alabama-Georgia game Monday
And President Trump's expected attendance, according to the Atlanta Journal-Constitution , adds to security concerns. This means that security will be heightened with the Ppesident attending the game at Mercedes-Benz Stadium.

Justin Timberlake Drops "Filthy" Video, Channels Steve Jobs
It shows him playing an inventor and channeling the late Steve Jobs at a product reveal event. That video was followed up with what looked to be a possible album or song cover.

Russia: US Call for UN Meeting on Iran "Destructive"
She added that it would be "telling if any country tries to deny the Security Council from even having this discussion". Graham echoed Trump's support for the protesters.

Texas flights see weather delays, cancellations
They were among more than 4,900 canceled flights across the United States, according to the FlightAware flight tracking site. The average flight is being delayed 16 minutes thanks to weather-related issues sich as de-icing planes and snowy runways.

Hot air balloon carrying tourists in Egypt crashes
A health ministry spokesman said that two of the wounded were in serious condition. Hot air balloon incidents have occurred in the past over ancient Luxor.

The World's Safest Airlines For 2018 Have Been Revealed
BRITISH Airways and Virgin Atlantic are the only two United Kingdom airlines featured in the top 20 world's safest airlines . Colorado's Frontier Airlines is a new entry on the 2018 list , taking a slot vacated by Singapore's Jetstar Asia.

Alexa Will Soon Control Connected Microwaves
But then, Apple wasn't first in the smartphone game either - and we all know how that turned out for the Cupertino company. The skill enables customers to easily configure, start, and operate their connected Whirlpool microwaves.

All Macs, iOS devices affected by chip security flaws - Apple warns
Apple is also working on patches and updates to defend against Spectre and will release them as and when they're ready. The flaws were discovered by researchers at Google and academic institutions previous year but were kept secret.

Federal marijuana policy change raises significant questions
Colorado is among eight states that have legalized marijuana for recreational use. MA and possibly ME are expected to begin sales this year.